Deep in a restricted corner of the Amazon, ex–black ops tracker Rafe Cortez (Dwayne Johnson) is hired by a ruthless pharma conglomerate to recover a missing research team—and the miracle serum they were testing on local wildlife.

Forced to partner with Dr. Lena Voss (Charlize Theron), a brilliant but uncompromising geneticist who led the experiment, Rafe discovers the truth: the serum didn’t just enhance an apex predator… it awakened an ancient species of anaconda that learns, plans, and defends its territory with terrifying intelligence. As flooded forests swallow their boats and satellite comms go dead, the team is hunted one by one in mangrove tunnels, half‑sunken temples, and pitch‑black river caves where the water itself seems to breathe.

When Lena realizes the creature is building a nest big enough to unleash an entire brood into the wider world, she and Rafe must decide whether to escape with the data that could save millions—or stay and face a living, coiling extinction event. The trailer ends on a nerve‑shattering shot: a helicopter lifting off as a colossal serpent rises from the canopy, wrapping the entire clearing in scales.