In the glamorous yet ruthless world of Hollywood, aging TV star Elisabeth Sparkle (Demi Moore) faces a devastating blow on her 50th birthday. Fired by her sleazy producer Harvey (Dennis Quaid) because she’s “too old,” Elisabeth discovers a mysterious black-market drug called The Substance.

This experimental serum creates a perfect younger version of herself — Sue (Margaret Qualley) — vibrant, seductive, and ready to reclaim the spotlight. The rules are simple: alternate every seven days. But as Sue’s rising fame consumes their shared existence, the boundaries blur, triggering grotesque body horror and shocking transformations.

With fearless performances from Demi Moore and Margaret Qualley, and a wildly over-the-top turn by Dennis Quaid, this bold satire from director Coralie Fargeat explores ageism, identity, and the obsession with youth in the entertainment industry. Supporting cast includes Edward Hamilton-Clark as Fred, Gore Abrams as Oliver, and Oscar Lesage as Troy.
Prepare for visceral thrills, dark humor, and unforgettable visuals in this audacious body horror masterpiece.