Week 18 is meaningless for several teams.

After locking up the No. 1 seed in the AFC, Patrick Mahomes and Travis Kelce will have two-plus weeks of rest before beginning the Chiefs’ pursuit of the first-ever Super Bowl three-peat. The Bills will sit their starters, as the No. 2 seed in the AFC. The Eagles will do the same as the No. 2 seed in the NFC, denying Saquon Barkley the opportunity to break Eric Dickerson’s single-season rushing record. Others (Seahawks, Cardinals, Cowboys, Colts, 49ers) are in purgatory, eliminated from playoff contention and unable to land a top 10 first-round pick.

Still, as many as 10 games this weekend could have playoff implications, while four teams remain in contention for the first pick in the 2025 NFL Draft.

These are the biggest storylines to follow in Week 18: