Decades have passed since legendary warrior-priest Ivan Isaacs (Jason Statham) vanished into the wasteland, believing the vampire menace was finally extinguished. But in 2026, a terrifying, evolved breed of nocturnal monstrosities rises from the ashes of the old hives, threatening the last bastions of human civilization. Isaacs, now a battle-scarred elder bearing the heavy burden of his past crusades, is dragged back into a war he thought he finished.

He finds the remnants of the Church have resorted to desperate, forbidden measures: creating a younger, genetically enhanced clone of Isaacs himself to serve as the ultimate weapon against the new darkness. This uneasy mirror image of past and present must reconcile their shared soul to face the encroaching evil.

They are aided by the mysterious Sister Augusta (Charlize Theron), a rogue priestess wielding arcane powers that predate the Church itself. As the supernatural horde sweeps across the desert, their path converges with the ragged edge of human resistance, led by hardened soldiers Elena (Michelle Rodriguez) and Marco (Cristiano Ronaldo),