In the heart of the jungle, where the air is thick with danger and the world’s oldest creatures still rule, Dr. Sarah Carter (Scarlett Johansson) must confront the terror she thought was left behind. After years of research and caution, a new, monstrous serpent emerges — an ancient breed of anaconda, larger, faster, and deadlier than anything humanity has ever known.

The jungle is no longer just a habitat; it’s a living nightmare. With every step Sarah takes, the weight of her past decisions presses down on her. The air smells of fear, the sounds of unseen predators all around, and the suffocating tension builds as the team faces a threat beyond their control. As the battle between survival and extinction unfolds, Sarah is forced to face not only the terror of the jungle but her own inner conflict — the pursuit of knowledge versus the cost of human lives. The world she once thought she understood now threatens to consume her in ways she never imagined.

In the face of this deadly predator, Sarah must find a way to outwit a creature that has evolved for millennia, while also questioning the true cost of her quest for discovery. Will she survive, or will the jungle take its final revenge?